More information about B6 (pyridoxine), esp. in the form of P5P (Pyridoxal phosphate), esp. dosage:
It converts 5-HTP (so also L-tryptophan) and glutamine into GABA, increasing serotonin, so best 25mg in the evenings
SAM inhibits it, so I guess also SAM-e/SAMe, so wdnt make sense taking P5P together with SAM-e. (However I’m not taking SAMe any more anyway at the moment, too many sfx, too few fx.)
Dosage: Most say about 50mg. Here it says " In the largest clinical trial to date, pyridoxal phosphate dosage of 250 mg/day (for 30 days) was safe, but it had limited efficacy. A higher dosage (750 mg/day) provided no further benefits [76, 77]. Lower doses (50 mg) may be sufficient for sideroblastic anemia."
Earthclinic says 50 mg 3x/d for trigger finger, praps best with Magnesium. Good for depression, sleep, brain health, neurotransmitters, energy, neuropathy, praps edema, joint pain, but motility (ehmm… don’t need that…)