Taken serrapeptase for Ache (5 of 7) at 12:20: fx (1) & sfx (skin & stool slight) immediately & surprisingly.
Same on 4th trial after mask-talking/working, Ache from 5 down to 1 in 25’.
Dr. JayKills log book Sep 4th, "1921": From 14:20 on: After Ache went down immediately, slight skin & pain sfx almost gone, also the cotton wool feeling, different stool. 1.5h Weeding no problem!
12:15 OK, pretty high Ache of 5 of 7 now, after talking or rather listening to someone for 50’ while playing a bit of table tennis. Good time to try serrapeptase, as it might help or cause even more muscle ache. Also this Ache could be interpreted as seeming slightly “inflammatory”, altho I have no feverish-feeling.
It’s 12:20, Sep 4th (wrote Dr. Jekyll… ) and I have now taken 1 capsule (it says 1-2). If that’s too much I can always open one and just use a part of it.
My first reactions at 12:30 if I listen closely, while sitting are: my Ache has stopped - very unlikely, that never happens, esp. not after only such a short time; see what happens when I get up. Slight pain in my right (not left) jaw & slight itching and pinpricks alternating on arms, legs, neck, possibly nocebo, and about the amount I’dve had if I’dve cold showered, so tolerable if it doesn’t get worse.
Getting up at 12:35: No Ache!? Hmm. But movements are slightly changed, looser, a bit stiff at the same time, but less than I’d usually have now. Scratching my neck, bit irritated there. Bit like “walking on cotton wool” or how’d’you call it, sort of soft, but at the same time something slightly stiffer in my legs. Something in my head. Never ever had this quick reactions.
12:50 Slightly itchy face and chest. Got my whole body thru, but all tolerable, since not all at the same time.
13:00 Suddenly tired in my head and my fingers (very dry), no Ache, but slight pains, slightly itchy backside,
13:05 slight left wrist pain, all others gone, slightly itchy scalp & still backside, all others gone. Ache still hasn’t returned. Still a bit cotton wool I think in my head? Itchy chest…
14:10 Nothing’s got worse, the itchiness is still tolerable, no GI (yet), the Ache is still gone, and I’m raring to do something active & see what happens.
14:35 Still researching the studies. Sudden strong stool, very light in colour. Might be normal. But my gut reacts quickly to everything.
16:45 After 1.5h of gardening/yardwork, mainly weeding, I am of course a bit tired, muscles sore and Achey, but not like I’d usually be…
17:38 Typing (fw) & resting, but not cos it’s nec. I think I’ll go to the shops a bit now.
The HPMC capsules are partly acid-protected by magnesium stearate
The capsules are not enteric-coated, they are HPMC/vegan, so I drank quite a bit (soy drink, not water), to get it quickly thru my stomach acid which 30’ before eating, like they recommend, will be pretty high. Worst case the enzyme will be destroyed by the acid and not do anything…
Going thru what it says on the capsules I’m not sure what the inulin is for, but I’ve just sorted out that the magnesium stearate slows down the dissolution. That explains the colour of the capsules and that it might get thru the acid. But surely dissolving slowly means it can’t be working yet, can only be placebo? But: Who cares!
Studies hardly mention sfx, nocebo
If I’m exchanging the Ache for slight pains and/or itches, that’s a deal, I’ll sell my body to serrapeptase…
Scanning the links I listed above, they say I may get skin or gut problems, and the Ache may get worse instead of better, muscle & joint pain. However going thru the articles, I cannot see that the studies used as proof are truly referring specifically to serrapeptase or are more than anecdotal.
draxe cites this study for skin, which is actually only one case history (direct pdf) of a man with an abscess, which was greatly exacerbated, praps due to the fibrinolytic activity of serrapeptase.
Whilst old.serrapeptase provides best information about not knowing what dose to take, it claims there are no sfx.
One of the German ones points to 2 articles, this one (also found here), which only cites 2 others, arguing to use it topically instead of via gut/orally: The first (7) isn’t linked or searchable. The 2nd (8) Topical formulations with superoxide dismutase: influence of formulation composition on physical stability and enzymatic activity - PubMed doesn’t mention anything about sfx in the abstract, it’s just also about using it topically, and trying to click on the full text doesn’t get me anywhere, so I can’t check it and this helpful one from 2017 says: “There are not many published articles on the adverse drug reactions (ADRs) to serratiopeptidase. The only information may be obtained from drug company monographs. The ADRs include allergic skin reaction that ranges from dermatitis to extreme cases of Stevens-Johnson syndrome or erythema multiforme, muscle aches and joint pains, gastric disturbances like anorexia, nausea, and abdominal upset, cough, rarely pneumonitis , and coagulation abnormalities. It has to be taken on an empty stomach or at least two hours after eating, and no food should be consumed for about 30 minutes after the ingestion of serratiopeptidase. The recommended dose of serratiopeptidase for specific indications, in particular, has been not mentioned anywhere; however, serratiopeptidase-based drugs commonly range from 30000 to 60000 UI/day.” - I wonder if my soy drink counts as food? 30.000 UI: UI seems to be the same as IU, international units, in this case probably SPU? The drug I very often get skin and/or gut, if it is listed in ADR lists, but not always, and I can play with the dose if it dose, ehm: does.
The other German link repeats 3 cases of pneumonia and adds that Zn or Mn may help.
Also seen that the “miracle enzyme” link above is total crap; if I could still edit it, I’d hide it more. Sorry.
Dose 10,000 SPUs, 0,3-1% of what's recommended.
What dosage of Serrapetpase should you take?
“The Serrapeptase dosage most commonly used in scientific research has been between 10 mg and 30 mg per day, but this suggestion is useless since the enzyme strength or activity is unknown. Unlike vitamins or herbal supplements, the most effective Serrapeptase dosage depends more on the potency of the Serrapeptase enzyme rather than the amount taken.” This site says 300,000-1,000,000 SPUs, which I am taking 0,3-1% of…
Interactions: Magnesium glycinate new this morning did nothing by midday.
Whatever: I have to remember I took 2x400mg magnesium glycinate very early this morning, however had absolutely no fx, neither relaxing, nor excitatory. Only when I realized the Ache is pretty high, did I think it’s a good time to try something for pain, and I’ve only got this left on that list.
2nd try Sep 7th: Deliberately overdid table tennis (70’ fairly full power, without breaks), Ache of 5. Taking serrapeptase seemed to stop the Ache quickly, this time no sfx/nocebo, just normal sports exhaustion. My acupressurist asked for some to try.
3rd: Sep 9th 19:45, after recovering from late 50’ power-TT took over half an hour… (yes, I’m getting quite demanding…). 20:25 starting to get a bit better, but can’t really say it’s that. And it’s not waking me up more, so won’t disturb getting to sleep.
The 1st time was emotional fatigue from socializing, not physical fatigue from TT like the 2nd & 3rd time, maybe that’s what it’s better for, for me?
My colleague took 4, my acupressurist 20, let’s see if it’s OK for them too.
The 4th time was 2021-09-10 9:30 an hour of working/mask-talking, Ache after of 5. 1x10,000 serrapeptase at 10:40 hadn’t worked at all by 10:55, but by 11:10 it was pretty much down to 1. And nothing I did after (mask-talking again 20’, commuting, 70’ power table tennis) changed that. No sfx by 17:15.
However I’m pretty tired all day due to waking up with strange pains after 4:00, slight, but disturbing sleep, so I was partly dozing and had to intervene, e.g. with a 1’ cold shower. Only explanation I can find is taking serrapeptase late yesterday evening after table tennis - which didn’t help much, caused light coloured stool in the morning, and may have increased skin problems to skin-nerve kinds of problems…?
Trying to understand how serrapeptase as a proteolytic enzyme works, it has become clear that it ‘lyses proteins’, i.e. splits bigger ones up into smaller ones, amino acids, which is what they do in our guts as well as apparently in our blood vessels, which helps reduce inflammation.
That now might explain why serrapeptase seems to be helping, like amino acids already do: All proteins?
This study from 2001 Therapy with proteolytic enzymes in rheumatic disorders - PubMed mentions various proteolytic enzymes changing cytokines which are at least a biomarker of FM, and are also a varied group of (small) proteins. I can’t find evidence that this also includes serrapeptase itself, however.
Similarly some proteolytic enzymes apparently help IBS, however I can’t find the same for serrapeptase.
Addition 2 2021-09-11: This site (Robert Redfern, “Good Health Club”) goes into a bit of depth regarding serrapeptase, comparing products, units, enteric-coating, BUT it’s trying to place its own products and (to do this?) has jumped to the bandwagon conclusion that FMS is (only) an autoimmune & cytokine problem for which there is nothing like enough evidence, despite Goebel’s 2021 study on mice. Next to buying loads of their nutrients their suggestions of how to eat, drink & breathe/exercise are fully OK. The nutrients most recommended for FMS/CFS don’t have much in common with what others suggest or research, like iodine, and the main products contain 77 or 43 nutrients…
Healthline’s article connects directly to studies, altho it’s always worth checking if they hold what articles promise.