I’ll dig out this old thread, if that’s OK, cos I think it’s got valuable discussion on it, in days apparently when TJ had a bit more time for us… 
And I’m adding a few pubmed studies, incl. one from Jan21 saying that cryotherapy helps get the cytokines under control! -
I thought I’d written about it here somewhere else, so if you can find where, remind me.
I’ll give a bit of my background on what I’ve read about it.
This Fm/a-test claims to be very accurate (the % they mention varies…). It measures proteins called cytokines & chemokines. Problem is this is a very idiosyncratic hypothesis, not as yet proven by studies. The background of the people behind it seems to me to be it a bit dubious. (Lastly they originally claimed to be developing a vaccine for it, based on their hypothesis. Thankfully at least they’ve dropped this last claim… - ehm, not sure about this, that was the last I read, a few months ago). Nothing could get me to do anything with these people after reading their side of things, checking on their claims and what the other side says about them. I won’t say scam. Praps cytokines will someday be a diagnostic help. But it isn’t. And other docs aren’t taking this particularly seriously.
The research I can find on pubmed:
“Fibromyalgia and cytokines” 2014, Current evidence suggests that cytokines and especially chemokines may have a role in the pathogenesis of this syndrome. Cytokines are small soluble factors that work as immune system messengers. They can be classified as pro-inflammatory and anti-inflammatory cytokines. Chemokines are a special kind of pro-inflammatory cytokines that guide the movement of circulating mononuclear cells to the injured side. Some pro-inflammatory cytokine levels (i.e. IL-1RA, IL-6, and IL-8) and, recently, some chemokines’ levels have been found to be increased in patients with fibromyalgia. Thus, herein we review the current knowledge regarding the role of cytokines in fibromyalgia patients and their possible clinical relevance.
“Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37”: Mast cells are involved in FM by releasing proinflammatory cytokines, chemokines, chemical mediators, and PGD2. Ah, I’d heard of mast cells before as a new FM-theory.
Interesting to me cos of my whole-body cryotherapy is this one: Serial whole-body cryotherapy in fibromyalgia is effective and alters cytokine profiles" - very new: Adv Rheumatol. 2021 Jan 13;61(1):3.
OK - if it’s gonna make you try whole-body cryotherapy, like me, I’m with ya…