Phhhhoo - what a scary scenario you’re scetching, TJ!
Thanks for your warning tho… - I’m all for knowing the dark side of everything…
But let’s see…
I’ve studied about 30-40h on GABA - so surprising that your information has eluded me up to now…
Your liver disease (mis)quote is from a study about the POSITIVE fx of GABA on the liver
I’ve found your above quote “GABA has long been viewed as a by-product of liver disease and contributes to hepatic encephalopathy” in this study
which is about GABA protecting against severe liver injury.
Your quote is also cut off. It goes on to say “in patients with cirrhosis” - I have no liver disease and no cirrhosis, so I don’t see the relevance. To the contrary: if I had liver disease I’d have too high levels of GABA and adding GABA would according to my logic cause serotonin syndrome, so immediately sfx.
What follows this is a list of neutral to positive influences, incl.
reduces chromosomal abnormalities
decreases malignancy potential
stimulate DNA synthesis for regenerating livers
protective role of GABA signaling against acute liver injury
advantageous effect of GABA in … hepatectomy and a … partial liver transplantation
enhances antioxidative countermeasures and improves mitochondrial function.
The alcohol-alcoholism comparison is only a warning against ALCOHOL...
I’d see as a slippery slope argument which clearly more than anything else admonishes yourself to keep those Scotch bottles carefully locked away as you are already almost an alcoholic (your own implication… )
GABA does NOT buzz me, it alone IMPROVES 10 symptoms, with no alternative!
As opposed to alcohol creating a social help & buzz out of the ordinary, what GABA is doing to me is only returning my life in part to the health I used to have, nothing buzzy, nothing different, nothing extra, no artificial, unnatural feelings. That is also my criterion for other things I’m trying, like ribose (similarly taurine before): In a higher dose it makes me feel artificially feverishly slightly over the top (taurine very much so), which is something I want to avoid in all cases, because it doesn’t feel right, natural and might make me overdo things and crash, like alcohol does - but GABA does not.
Also: Someone who feels the need to drink alcohol to take part in normal life has alternatives in therapy. I don’t. If I stop GABA, I will have to reduce my activities again, go back on sick leave and retire. Remember I have been to 46 docs, 15 physios and tried >100 treatments in the last 2 years and GABA is the only thing that has helped, even if it’s not a cure. Are you really warning me to stop it? And what then?
I don't have NCSE/those sfx, my seizures are REDUCED by GABA
Similarly your quote about “nonconvulsive status epilepticus”, which I can only find anecdotal evidence for in studies like this one about tiagabine in a 27yo. Here they are saying that this, which increases GABA, might occasionally be a problem for people without epilepsy, whilst people with partial seizures are given it. But I do have these, and they got less - due to taking GABA. Also I have never had any of the fx you have mentioned, nor any of the symptoms of NCSE. When I overdose, which as I said creates a GABA shunt and “serotonin syndrome”, which are a different set of symptoms, and sets 3-5 of my symptoms back to the way they were when not taking GABA, but not all 10. That only goes to show I need to keep the dose moderate, not to show that I should stop taking it - doesn’t it?
My doc says to do all this it MUST BE crossing my BBB. And docs rule, you say...
I had the same thinking that it might not be crossing the BBB. More importantly than your liver example it seems to be produced in the gut biome. But looking at research and asking my sleep lab psychiatrist, these explained otherwise - that my successes with it show it MUST be crossing the BBB and has nothing to do with my biome or liver. And according to moderator wisdom I should listen more to docs who know me than to things I read on the forums .
My doc says it helping more than a few months proves it also can’t be placebo any more, and to definitely continue with it.
The leaky brain hypothesis caveat against taking GABA is not convincing.
Have you read any of the studies or many (long-term) experiences about the positive effects of GABA?
The only - fairly - real caveat I’ve found up to now is the “leaky brain theory hypothesis”. I’ve spent hours reading and pondering on this, but find it even less convincing (and applicable to my body) than the “leaky gut theory hypothesis”, and it has also recently been very much revoked by the originator of the so-called “theory”. Again according to research and my doc, this hypothesis is rubbish.
So, if I’ve still missed something:
Could you cite your sources? Or explain further?
Of course I’m now worrying , but at the same time I can’t at all see why I should be!