Actually, it is only the 50 mg tab prescribed for opioid abuse that means you can’t use opiates. LDN is only taken .5 to 4.5 mg and has no interaction with alcohol. You can continue to use both LDN and opiate pain meds if you take them 12 hours apart. I worked up to 2.5 mg from .5 and then had a nasty reaction that worsened my fibro so I stopped. My symptoms quickly went back to their usual level. Response to LDN and dosage are very individualistic, though, and some people get tremendous relief. I may actually try it again at 4.5 mg. I would try it, the risks almost none and the potential gains are great.