It’s a very odd med, IMO, aspects well known at 50 mg and above but poorly researched for fibro, a few small studies with no follow up, at the LDN dosages. There seem to be individual dosage windows for people such that slightly higher or lower doses have great impact. I truly experienced the worst fibro symptoms in 25 years on it but they went away. Maybe I need a higher dosage!? I haven’t been able to get myself to try again even though the effect only lasted a few days. Depending on the fibro, I may try again. I’d hate to think some simple med could help. I did have to take in the AM, maybe not optimal, as I experienced vivid and unpleasant dreams when taken at night, perhaps the only adverse effect I’ve seen reported. If I had an M.D. with experience in dosing it working with me I’d certainly try it, I had to order it overseas on my own. I have an appt. with yet a new rheumi in a month so see if he knows about it. Wait until I tell him I got certified for medical marijuana here (MA) but I am waitng for dispensaries to open and that’s undoubtedly a different thread!