Awareness for my friends: Drug Induced Lupus - many Overlaps with fibro

Recently I have been undergoing tests as I’m long overdue. In getting tests done by new rheumatologist it appears likely that I have drug induced lupus.

Since so many symptoms are overlapping with fibro, I thought it was worth posting some information. Suggest that you look at medications you are on and compare to the list of drugs that can cause drug induced lupus. This information can be googled.

In my case, Minocyclene(an antibiotic) was prescribed for acne and blood work wasn’t done for over a year. Since stopping Minocyclene I have not noticed a change of fibro symptoms. However, I’m still hopeful things might change

Be Well,


information from the Internet:

Drug-induced lupus erythematosus is an autoimmune disorder that is brought on by a reaction to medication.

See also: Systemic lupus erythematosus (SLE)

Drug-induced lupus erythematosus is similar to systemic lupus erythematosus (SLE). It is an autoimmune disorder, which means the body mistakenly attacks healthy tissue. It is caused by a hypersensitivity reaction to a medication.

The most common medications known to cause drug-induced lupus include: isoniazid, hydralazine, and procainamide. Other medications known to cause drug-induced lupus, include:

Anti-seizure medications
Symptoms tend to occur after taking the drug for at least 3 to 6 months.

Persons with drug-induced lupus erythematosus may have symptoms that affect the joints (arthritis), heart, and lungs. Other symptoms associated with SLE, such as lupus nephritis and nervous system (neurological) disease, are rare.

Blurred vision
General ill feeling (malaise)
Joint pain
Joint swelling
Loss of appetite
Pleuritic chest pain
Skin rash
Gets worse with sunlight
"Butterfly" rash across bridge of nose and cheeks
Weight loss

Exams and Tests
The health care provider will listen to your chest with a stethoscope. The doctor may hear a sound called a heart friction rub or pleural friction rub. There may be signs of pericarditis.

A skin exam shows a rash.

Tests that may be done include:

Antihistone antibody
Antinuclear antibody (ANA) panel
A chest x-ray may show signs of pleuritis or pericarditis. An ECG may show that the heart is affected.

Usually, symptoms go away within several days to weeks after stopping the medication that caused the condition.

Treatment may include:

Nonsteroidal anti-inflammatory drugs (NSAIDs) to treat arthritis and pleurisy
Corticosteroid creams to treat skin rashes
Antimalarial drugs (hydroxychloroquine) to treat skin and arthritis symptoms
Very rarely, high doses of corticosteroids (prednisone, methylprednisolone) and immune system suppressants (azathioprine or cyclophosphamide) are used to treat persons with severe drug-induced lupus that affects the heart, kidney, and neurological system.

Protective clothing, sunglasses, and sunscreen are recommended.

Outlook (Prognosis)
Drug-induced lupus erythematosus is usually not as severe as SLE. Usually, the symptoms go away within a few days to weeks after stopping the medication.

You should avoid the medication in the future, or symptoms usually return. Routine eye exams are recommended to detect eye complications early.

Possible Complications
Thrombocytopenia purpura – bleeding near the skin surface, resulting from a low number of platelets in the blood
Hemolytic anemia

Hi Sunflower,thanks so much for this info,i am going to now mention this to my rheumy,when i go next,just waiting for app,so how long i have to wait,is anyones guess!!hope you are having a pain free day!!

Hi Sunny,

Sorry i've missed your thread being on LWL.

Drug induced Lupus is'nt an A1 Disease such as Lupus itself or Fibro... it's an autoimmune Disease but is also caused by fibro, as we have member's who have Lupus besides Fibro and i'll explain the best i can the difference but refering to Raynauds which i have also.

Raynauds is an A1 Disease...where you get scleroderma involved with it (serious autoimmune disease)then psoriasis another autoimmune Disease...with these complications off the autoimmune diseases following Raynauds it then turns into DLE...i hope you can get my drift concerning the differences.

As induced Lupus gets stronger then it can cause your ANA to change but drug induced Lupus known as DIL is still not as strong as Lupus SLE itself through being an autoimmune Disease.

If it's only slight in your system your doctor will give you none steriod anti-inflammatory meds (NAIDS) but if it's alot stronger where it starts showing up in your ANA/DNA this is usually what patients and doctor's wait for for showing positive with Lupus so they can get treated unless the doctor see's symptoms out of the criteria showing 4 or more, then you doctor treats you with stronger meds...such as steriods.

Sunny as your Rheumo said how strong it is to you?

This link is also helpful for different types of Lupus

Hugs Terri xxx

Isn't it strange that the very first drug given to me for Psoriatic Arthritis, an autoimmune disease, was Sulfasalazine. The Rheumatologist said that the Insurance Companies dictate which drug you begin treatments with. Fortunately only took it for 3 months, before getting a stomach ulcer!

Sunny, I hope this can be easily remedied. You already have far too much going on without this worry! I am glad that you are finally getting some answers though. As always, I send you my very best!



Just read this, Sunny, and am stunned! I'm glad you brought this to our attention because at least one medicine used for fibro, Lyrica, is an anti-seizure medicine, so might be involved. I'm really sorry that this has bitten you in the butt HOWEVER it looks like discontinuing the meds will make the induced lupus go away. Terri's message helps to make the connection and results clearer. I'm hoping that you can walk away without a scratch, so to speak.

Glad you checked in with us and told us what's going on with you, as well as informing us of this possibility. This disease and its treatments...ya gotta luuurve it, huh?

Get well, Sunny. Get that lupus outta your system, girl!



Hello Petunia,

If sunny is able to find out what degree she as it at and it's only mild the NAIDS can do that but more serious then it's stronger steriods.

Petunia Lyrica besides other anti-seizure drugs can cause nerve damage besides...there's many issues to these drugs as i have nerve damage and some drugs can affect the nerves that bad and besides the mays well have been having ECT....actually Sunny as opened up a good discussion here on her health..i hope they can remove the Lupus as fibro on it's own is enough to deal with but it can open up other avenues on drugs and symptoms besides.

I think you and other member's will find this link interesting besides.

Hugs Terri xxx