Is it just me or does Cymbalta make you kinda high? just got my perscription todady 30mg of cymbalta every morning.

Makes me sweat loads and feel tired, for that reason I would honestly advise you take it at night unless there is a specific reason for taking it in the morning. Mikex

You are young though (judging from your picture) and they are not recommended for people under 25 because studies show suicidal thoughts (which I would say are down to the depression they are treating in some people).

There are safer drugs for depression but cymbalta helps with pain apparently. I am on 60mg and notice no difference in depression or pain :(

Awww thanks! I'm 30. My doc seems to think they will help so I'll give em a shot for a while. I do like the idea of taking them at night though.

NOT good at all! Glad you got off it!

If I am honest I just thought everyone took them at night anyway unless they are night workers. Just do whatever feels more comfortable to you. If you find you are excessively sleepy then maybe ask for 15mg tablets and take one in the morning and one at night. xx

I don't take Cymbalta but Lyrica is a similar type of drug used for fibro and I find it helps a bit. I hope you get some relief!

Cymbalta is a SRNI type antidepressant and Lyrica is an anticonvulsant usually used in epilepsy. They both have the same common side effects though. You can take both at the same time (like me). The reason Cymbalta (Duloxetine) is used is because it reduces the likelihood of serotonin syndrome and painkiller interactions compared to other antidepressants and has a pain killing effect as a bonus. Mikex

:) go doctor Mike!! No one told me to take it at night so I took one when I got home.

Happy to help any time. If you have any other problems you can always ask me and I will do my best to help you. Mikex

WoW!! That's impressive, Mike! I had no idea of all of that.

Now, some explanations, hopefully. WHAT is serotonin syndrome? And also, since I've been taking Lyrica, my arms and legs seem to jerk when I'm asleep. If it's an ANTI-convulsant, why am I twitching? Okay that's a question to ask my doctor...sorry.

I was on Cymbalta for a while. I never experienced any of the tiredness. I took mine in the morning. The only thing I did have was that I couldn't even increase to 60mg because it gave me hand tremors. But I believe the therapeutic dose for fibromyalgia is 90mg.

Here's the PubMed definition of it.

"Serotonin syndrome most often occurs when two drugs that affect the body's level of serotonin are taken together at the same time. The drugs cause too much serotonin to be released or to remain in the brain area.

For example, you can develop this syndrome if you take migraine medicines called triptans together with antidepressants called selective serotonin reuptake inhibitors (SSRIs) and selective serotonin/norepinephrine reuptake inhibitors (SSNRIs). Popular SSRI's include Celexa, Zoloft, Prozac, Zoloft, Paxil, and Lexapro. SNRI's include Cymbalta and Effexor. Brand names of triptans include Imitrex, Zomig, Frova, Maxalt, Axert, Amerge, and Relpax.

Symptoms occur within minutes to hours, and may include:

  • Agitation or restlessness

  • Diarrhea

  • Fast heart beat

  • Hallucinations

  • Increased body temperature

  • Loss of coordination

  • Nausea

  • Overactive reflexes

  • Rapid changes in blood pressure

  • Vomiting

    To be diagnosed with serotonin syndrome, you must have been taking a drug that changes the body's serotonin levels (serotonergic drug) and have at least three of the following signs or symptoms:

    • Agitation

    • Diarrhea

    • Heavy sweating not due to activity

    • Fever

    • Mental status changes such as confusion or hypomania

    • Muscle spasms (myoclonus)

    • Overactive reflexes (hyperreflexia)

    • Shivering

    • Tremor

    • Uncoordinated movements (ataxia)"

My psych says that she's seen serotonin syndrome in cases where they were adding or adjusting meds that do not even interact with the serotonin. It can be extremely serious and you can be hospitalized. My psych had a young boy hospitalized for 2 weeks over it.

I was on Cymbalta for years for my depression. But when I was diagnosed with Bipolar the Cymbalta wouldn't work with any of the other meds (mood stabalizers). So they took me off of it and tried other meds. The detox of that was horrific. I should have hospitalized myself. I was hallucinating, had the shakes, and many other things. This lasted for days. I was also on a higher dosage since I was on it for so long and built up a tolerance. I wonder if the Cymalta kept the Fibro pains at a low all of the time I was on it. But I am afraid to stop taking what I am on right now, which helps reasonably. But I often wonder if I were to get back on the Cymbalta, if it would help my Fibro pain and how it will or will not help my Bipolar.

Thanks, I’ve read about withdrawal symptoms and hope its not as bad as quiting smoking.

I'm soon to start cymbalta. Does anyone have any experience with zoloft vs cymbalta? I have to come off zoloft which has been working really well for my anxiety, but does nothing for the pain.

Its suzyq I took cymbalta it didn't help but no sideaffects hey Mike I also didn't know ut was ti be taken at night

Okay odd question here, but how do I know what drug is causeing a side effect or is it just fibro. I'm all fogy today and it's not the same as usual. I know what fibro fog is like and this is different.