2022-09-21, Wednesday - Energy ?15% / Sleep 85% / Feeling 80%-ish
Successes:
jaw under control by relaxing, pillow up, stretching backwards.
Looking to the sun always makes me nauseous.
…
Learnt: 
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What’s so diuretic? Glutathione? B3?
Today’s symptoms sorted by the ACR 2016 criteria
Widespread pain, WPI = 11 of 19 areas: limb-Ache 8 (20%, stiff 15%) + spine-pain 3 (10%), shoulder-girdles/hips 0 chest / abdomen / jaw 0
Symptom severity, SSS = severity 9 of 12: Fatigue 3 (85%), insomnia 3 (15%), fog 2 (10%), headache 0, GI 1 (10%), depression 0
Triggers & resulting Symptoms
SLEEP (click for details): 9h21, up 8x (1h07), deep 7h. ✅ ➔ Feeling 80-90% well, Ache 2-1 of 7 ✅, getting up: 90%/2 ✅. Nostrils 5% stuffy 10% of the night. All despite tooth, the pain I got down by resting & relaxing before bed, pillow up, stretching backwards so my back doesn't suffer again.
cold shower p0 Sleep 22:05-
23:25 10’ 80%/2/10% p0 st1 sip fw1’ deep air HWB
0:50 5’ 80%/2/10% p0 st1 sip fw1’ deep
2:20 5’ 90%/1/10% p0 st1 sip fw1’ deep/doze A few work thoughts needed …
3:19 25’ 90%/1/10% p0 st1 sip fw1’ doze 6
4:12 9’ 90%/1/10% p0 st1 sip fw1’ doze hungry HWB FAS
5:25 4’ 90%/1/10% p0 st1 sip fw1’ doze/deep wind 2nd x (Threo?)
6:45 4’ 90%/1/10% p0 st1 sip fw1’ deep
8:06 5’ 90%/1/10% p0 st1 sip fw1’ doze B2-4
-8:33
Sum: 1h55+8h33-(10+5+5+25+9+4+4+5=)1h07 = 10h28-1h07 = 9h21, up 8x (1h07), deep 7h.
C1 & Meal & Sun 9:00-15
ACTIVITIES (aim: 40% energy) ➔ ACHE: online work ➔ 80%/2 
, wife says I don’t look as if I should be doing anything else, altho I was planning to go out for a little. 
ACTIONS ➔ PAINS: except: neck , GI , esophagus , jaw 1x5’’ , pee pain: 0xp1-2 , urge an hour after glutathione, every 20’.
(lie, sit, stand, arms up, cycle, walk, mask??)
MCAS/HIT-Symptoms/Triggers/Treatments: Fatigue better from acupuncture/sleep/cold showering as well probably as losing the CoV-antibodies. . Tofu? Nausea looking at the sun seem to me to be an MCAS oversensitivity.
Fibro & Touch:
Covid-danger:
Weather: Indoors Outdoors . Seem to be getting used to temperature at 18°C indoors (cos of gas inflation), wearing long johns all the time.
Treatments
Docs:
Tooth again on 20th, after body on the 6th took 8 days to calm down… But better this time, but only cos I immediately started to rest after I realized stress was increasing the pain.
Chinese Acupuncturist - #28 on 9th, after 28 days Still good. Session #29 on 23rd.
SELF-PHYSIO (click for details): ' Added '(looking to the) sun'.
airing 4x2’, cold shower 1x(10’), warm shower 1x(10’), cream/oil fc/ey/hd/ft 2x1’, teeth 3x2’, HWB 0x3’, breath exercises 3x1’, Timing, hunchback-pillow 0’, Y. Nidra 20’, massage gun 0x3’, neck 1+ 0x1’, neck 2 0x1’, plantar/calf stretch 1x1’, acupressure 0x1’, palpate 1’, belly 3’, back 10’, !!aloe vera 0x1’, twist-stretch 0x1’, yoga/stretching 0x1’, sun 2x5’.
Combine: next?
workout 7’, horse stance 1’, balance roll standing 5’, breath-hold 12’, jolt-jump 1’, marionette-hang 1’, shaking dance 1’, bent leg fall 1’.
Supps Sep 20th (34 supps): Supp costs:~389€/m (Sep 20th) CHANGED: Surprisingly increased energy after first(?) glutathione 19th at 3, so from 20th on at 9 and 3. Ordered eleuthero (Hirsch), magnesium threonate, apigenin, and myo-inositol on 17th (Huberman). Started flushing B3 from 17th, increasing without problems, probably 3x250mg/d by the 22nd, additional to continuing flush-free. 4 Quercetin from 14th on. B2 from 10th, remember to halve from 24th. Started fisetin and olive leaf extract (Berg) low on 8th, full 750mg capsules by the 15th. 1x150mg alpha GPC from Sep 5th, more when safe. B3 2x from Aug 31st (then check homocystein). Pure ATP 400mg in liquid was bad, so at most I may encapsulate & start with less, 100mg. Copper doesn't seem necessary if my cardio interpreted my bloods right. New idea: Creatine. PLANNED/TAKEN TODAY: click for details:
ZERO now: Arg, B2, Cu, Mum, Nc 1*.5g, (Nd), Pe, Ps, atm !Qc, Rib, Se, Sr 31125k, Zn.
REGULAR as of Sep 20th (34 supps): ALA .2g, alpha-GPC 1x150mg, B2 1x100/50mg, B3/Nia 250g & B3 flush free 400mg, B12 0x5mg/4m, C 2x.5g, Cr 6x0.6g, 0(-2) DAO before meals, D3 20.000 IE = 500mcg, + K2 (MK7) 200mcg, stopped increasing that, EGCG 1x(50%, incl. theanine?).5g, EllagicA 2 x.2g (+43mg vit. C) after a short break, Fev .4g (+.2g MSM), Fis: 1x196mg. Ga: now 3x0.4g+2x.6g=2.4g, Gi 3x168mg, Glutamin: down to 0.6g, Glutathione 2x, Hon (2%)x2x.4g=16mg, Luteolin .2g, Ω3 1x5mg, Mg Gly 2x50mg, Mg Mal 2x45mg, P5P 0x27mg, PEA 1x0.4g Pf 3(-4)x.35g, pine bark 2x.5g, PQQ 1, CoQ10 (ubn) 1x.1g, Qc 4x.5g, Rs (50%) 2x.4g, Ro 2x.35g, Rutin: 1x522. Sa .1g, Sily (80%) 1x.5g (+83mg L-cholin) , The 2x.2g (+.15g polyphenols).
What-when-details: Updated Sep 5th (before: see the reference post)
/19:40 400mg GABA A1/2 “19:00” PF#1+2 GABA#1 Cr#1+2, 2 mg mal, 0-1P5P, 0x50mg B2, 1PQQ, 5ml Ω3 & 0Qc. Meal: 1xHon. Q10.
Meal -21: Gum -
/22:05 400mg GABA A3 “21:00” PF#3 .3-.6?GABA#2 & .3-.6?glu & 1Lut (slp!) & 0Qc 1xHon + 0 Rupafin
/23:30 400mg + GABA
/08:10 B2-4 “07:00” +ALA+ now 2x pine bark, (teeth) +1Ro, 0Qc Rs#1 SAM-e EGCg + Fev/MSM + Sily +2The +Fisetin + (B1:)1x50mgB2 (100mg for 2 weeks)
Meal 9:00-15: Gum 10:-11: Teeth 11:05
/9:05-20 C1-3 “MEAL!” 2Cr#2 .6GABA#4, gink#1, 0 Zn, gly#1+2, 1x pine bark#2. .5gC#1 (0 NAC)+PEA + Rutin + vit.D3 1/wk. + 1x alpha-GPC.
/9:25 + glutathion
/?12:25 C4 “11:00” (+2h/) gi#2 1 Ellagic acid#1
0 Meal -15:15 Gum - (D1) “12:30”
/15:15 D2/3 “13:00” .5gC#2 , 2Cr#3, .6GABA#5, gink#3 DRINK!
0 + glutathion
/17:25 D4 “17:00” (“meal/acids+2h”) Ellag#2, Qc#4.Rs#2, +1Ro
eve:
“18:00” Prepare: 1) Cpl & chk/C supp-chg. 2) Remove “v”, cut, save, paste 1x & unhide & paste 2nd (+1 to date and ##). Close 2nd TAB!
(Nov 4th, Jan 10th: B12 5mg methylcobalamin s.c.; last: Apr 10th.)
The day's 16 supp-compartments (10', plus 5' making capsules), Sep 20th
Pf: 1A1+1A2+1A3, alpha GPC:C2. B3ff: C3,D3. B3f: A2,C3,D3. C:C3+D3 3x2Cr: A1+C1+D2, Ell: C4+D4. 4-5xGa: a2,a3,a4,C1,D2, Glutamin: A3,c1 Glutathione: C2,D2. Gi: C2,C4,D3 2Gly:C2 Hon:A2.A3. 2Mal:A2 Qc: A2.A3.B3.D4 Ro:B2,D4 Rs:B3,D4 SINGLE: 0P5+1Q1 (->ubiquinone <150mg/d!):A2. A3: Luteolin B1:B2,Fis.B2: ALA+2 pine B3:Sa. B4: 2Th EGCG&Fev/MSM&Sily C2:0Cu/Zn C3:PEA+Ru. (A2:Ω/Pq:meal) DAO before risky meals?
(A2:0Se), (B2:0mu), (0Nc: A3, B1,C1,C3,D2)
Development
‘Research’ today: Now regarding NAC/vit. C etc. vs. DAO/MCAS/histamine connection:
These substances compete with histamine in binding to DAO, so the solution I think is to accordingly supplement more DAO if necessary (esp. when adding more of it). At the rate that it is decreased, which was found to be 33% for amitriptyline, 29% for NAC and only 8% for B1 (in “test tubes”), unfortunately no % or even guess for C. (But only if that supplemented DAO gets to the right place in our body, I’d think. Otherwise reducing or stopping these supps - or meds - might be necessary. )
And vitamin C? Quite a few studies say it decreases histamine. But after following all links I still canNOT substantiate vitamin C decreasing DAO, and on the “table 2” it is down at the bottom, like B1, so maybe only a similarly small reducing effect, far outweighed by its decrease of histamine.
Rose hips as alternative to vitamin C may come from or via Hoffman “Be careful of citrus-based Vitamin C”. “You can also increase your DAO levels with high doses of vitamin C.” “may need a non-citrus source such as rose hips” But altho I like Hoffman’s recommendations I can’t follow the rose hip / non-citrus argument unless it means citrus fruits because of their biogenic amine putrescine (see details below).
NAC can also increase histamine in some people, that’s proven when given for paracetamol poisoning: Histamine release is the associated mechanism following acetylcysteine adverse reaction in man. Not only IV, also orally.
These are deeper and further details on what reduces (and also what increases) DAO.
The study testing for amount of DAO reduction: Evaluation of the inhibitory effect of various drugs / active ingredients on the activity of human diamine oxidase in vitro, Roland Leitner, Eva Zoernpfenning & Albert Missbichler, 2014: “Chloroquine and clavulanic acid showed greatest inhibition potential on diamine oxidase (> 90%). Cimetidine and verapamil showed inhibition of about 50%. Moderate influence on DAO was caused by isoniazid and metamizole, acetyl cysteine and amitriptyline (>20%). Diclofenac, metoclopramide, suxamethonium and thiamine [= B1] have very low inhibition potential (<20%). Interestingly cyclophosphamide and ibuprofen displayed no effect on DAO. Conclusion Since even levels of about 30% inhibition may be critical, most of the observed substances, can be designated as DAO inhibitors. Other drug components than active ingredients did not affect DAO activity or its interaction with a specific drug.” In the more detailed table from this study in the pdf on researchgate it says amitriptyline inhibits with 33%, acetylcysteine 29% and thiamin 8%, unfortunately no vitamin C.
The table in the 2020 article (Histamine Intolerance: The Current State of the Art - PMC) is based on a 1985 study and the quantifying 2014 study above and 1-2 more, all in vitro.
“In most cases, the structural similarity of the cited drugs with histamine could explain their potential to bind to the active site of DAO and reduce its enzymatic activity”
In that originally cited article it also says “The exclusion of foods could be based on their content of other biogenic amines, such as putrescine and cadaverine … citrus fruits, mushrooms, soybeans, bananas and nuts may be due to high levels of other amines, specially putrescine…”
This is quoted by several articles on researchgate, e.g. a 2021 article by Hrubisko et al. Histamine Intolerance—The More We Know the Less We Know. A Review “Approximately 20% of Europeans regularly take drugs that reduce DAO activity, which increase the risk of developing HI; these drugs include verapamil, clavulanic acid, chloroquine derivatives, acetylcysteine, amitriptyline, metamizole, and isoniazid.” or 2022 Sánchez-Pérez et al. The Rate of Histamine Degradation by Diamine Oxidase Is Compromised by Other Biogenic Amines “impaired DAO activity can also be temporary and reversible, arising as a side effect of some widely used pharmacological drugs, such as clavulanic acid or acetylcysteine, or a secondary symptom of gastrointestinal disorders. In fact, evidence supporting an intestinal origin of histamine intolerance is growing”. Interesting details in the pdf, summarized above.
DAO can help nausea in seasickness, which comes with increased histamine: Impact of oral vitamin C on histamine levels and seasickness - PubMed I think that’s what Hoffman meant to say (quoting that study) with his weird sentence: “Histamine (p < 0.01) and DAO levels were increased after the intake of vitamin C (p < 0.001) and after placebo (n.s.).” Histamine wasn’t increased from the vitamin C, it was increased from the waves/seasickness.
But DAO also decreases histamine and mast cell degranulation Food Intolerance: The Role of Histamine - PMC and “Deficiencies of copper, vitamin C, and pyridoxine may be possible reasons for the decreased activity of DAO”. “Deficiency of the DAO cofactors vitamin B-6, copper, and vitamin C, which are thought to supplement histamine degradation, has been discussed as being controversial” it says in Maintz et al 2007. But the study by Jarisch et al. 1996 is only available for 35€.
The mention of pyridoxine (B6 form) is interesting, cos several of these studies say it increases DAO. (So I’m glad I’ve supplemented it so much it’s way over the top.)
Other meds /supps and also biogenic amines in food inhibit DAO even more. Esp. putrescine, cadaverine, esp. high in unhygienically produced foods fermented with certain sorts of bacteria, 4x as much as histamine. So 20% of the histamine isn’t degraded. If they’re the same amount as histamine 10%. If not existent, then DAO gets the histamine down to 0%. (Sanchez-Perez et al 2022) That may explain why “histamine” is so complicated, for us with MCAS/masto and not just for HIT.
Lessons in self-care #430 Keeping moving down.
Reasons to be cheerful #431 Luckier or wiser after this tooth treatment.
- My food apparently minus broccoli…
- 1st Jab-sfx-summary, last edit: Feb 7th.
- My blog references, e.g. abbreviations, supp chart/overview
- My “How to symptom track & trigger hunt”
- Next up…: Summaries