JayCS’s Fibro Blog

Symptoms & Treatments
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2022-01-06, Thursday - waiting for DAO result; low histamine diet on ice…

v4: 17:30 Successor of my sleep lab psychiatrist was impressed and completely out of her depth with my problems
v3: 14:10 jab-sfx = histamine intolerance, allergic? DAO-level being checked, diet would decrease QoL, my GP says…
v2: 22:35: Nope, ALL except 2 of my 25 jab-sfx-symptoms as well as 4 more I hadn’t seen clearly before can be explained by histamine intolerance… :bangbang:
v1: 22:05: well, I’d have about 10 histamine intolerance symptoms etc…

Triggers & resulting Symptoms

SLEEP (click for details): h ✅, but ➔ Feeling ?70% well, Ache ?2 of 7 🧐, waking up: ❌

No fw! lbu: belly tensing? No half-sitting on sofa!
alternating shower p0 Sleep 00:25-
2:10 1h25 90%/1 p0 st1 drink fw55’ 6 overactive brain (due to research)
4:43 3’ 90%/1 p0 st1 drink fw1’
7:07 3’ 90%/1 p0 st1 drink fw1’
-7:50 52’ 90%/1 p0 st1 drink fw40’ overactive brain HWB -8:42- → Yoga Nidra
-9:58 = 1h16
Sum: 7:50-25-(1h25+3+3=)1h31 = 5h54, up 3x (1h31) +1h16 = 7h10
OR 9h58-25-(1h25+3+3+52=)2h23 = 7h10, up 4x (2h23)

ACTIVITIES (aiming for 40% - well 20% - of pre-fibro) ➔ ACHE: ➔ ?70%/2
(e.g. cycle :biking_man:, TT = :ping_pong:, meetings/social :speaking_head:, mask :mask:, kids :child:, work ➔ ?80%/2) ?:white_check_mark::x::face_with_monocle:
ACTIONS ➔ PAINS: :white_check_mark:
(e.g. lie, stand, loins, sit, arms up, neck, stiff, walk, cycle, 0xp1-2, GI, talk, mask.)

Treatments

THERAPIES:

  1. Going to therapy would take the 1-2h of activity I have on that day and the following - I just don’t have the time and energy for that.
  2. My GP recommended not to do a low histamine diet, cos it’d decrease my quality of life too much, just wait for the DAO result and then taking it as a supp if it’s reduced. However what if it doesn’t or doesn’t help??
  3. The successor of my sleep lab psychiatrist was impressed and completely out of her depth with my problems, e.g. which docs to consult or direct ideas on histamine intolerance as jab-sfx (like: NAC, vit. C/ascorbic acid & theophylline blocking DAO, the enzyme needed to decompose histamine, so why should I take them together to decrease histamine??)
    Supps to CHANGE: Wash capsule machine…:face_with_monocle: Up next: Try leaving off NAC and vitamin C, cos of the DAO contradiction, that I’m sposed to be taking them, but according to studies they decrease DAO…
SELF-PHYSIO (click for details): 3h40 ✅.

:white_check_mark: twist-stretch 25’, cold shower (7’), yoga/stretching 5’, hand-exerciser 3’, loins 5’, plantar/calf stretch 4’, HWB 3’, hunchback-pillow 30’, AuTr 1h16, palpate 1’, belly 3’, back 12’, neck 1+ 8’, left foot on/under right knee/cross-legged 30’, neck 2 3’, shaking dance 1’, cream 4’,
:x: Timing, teeth 3x2’, jolt-jump 1’, gums 2x30’’, V ‘, marionette-hang 1’, mirror 2’, breath-hold 11’, RR x2’, workout 7’, massage gun 20’, temperature 5’

23-24 Supps: PLANNED/TAKEN TODAY (click for details): NEW/IRREGULAR/CHANGED: Kept up ALA + pine bark. Nd 0. Arg, B3, Ri: 0 today. Pe & Ps 0? (23 REGULAR: B2 1x.1g, B12 5mg/2m, C 2x.5g, Cr 3x1g, D3 1/w, Ga: ~2g(4), Gi2, Gu:~1.2g(4), Ma3x2, Nc: 2.5g(5, incl. 2x1/night), Ω3, P5:1, Pf4, Pq1, Q10 2x1g/d, Qc 2x.5g/d, Rs2, Ro2, Sa1, Se1, Sr 3x1x125k, The.2g, Zn1)

Abbreviations resolved under blog references
What-when-details: Updated Dec 3rd (before: see the reference post)
/21:15 A1/2 “19:00” PF#1 Cr#1 mal#1+2 P5P/2Rho/0Se +/22:00 PQQ Ω3 = “PfCr Ml P5Ro Pq.Ω3”
/22:45 A3 “21:00” PF#2 .6 GABA&.4glu#1 NAC#1 = "PF+.6GaGlu+Nc
/00:25 A4 “23:00” PF#3 .3 GABA&.3glu#2 = “PF+.3Ga/Glu”
/02:50 B1 “01:00” PF#4 NAC#2 SRP#1 = “PF+Nc+Sr2”.
/03:25 B2 “03:00” +ALA+pycnogenol
(teeth))
/10:00 B3 “07:00” (30’) Q10#1 0quercetin resveratrol#1 SAM-e1, “Q1QcRsSa” + ?NAC#
B4 “Up”: 2xNADH#?
/11:00 MEAL! C1/2 “+30’=Meal” Cr#2 .6GAB#3,the2,gink#1, NAC#2,Zn=B2,C,Cr.GaThe Gi n’AC/Z
/11:30 C3 “08:00” .1gB2,.5gC#1, NAC#3+ “B2CNc”. Nut > grain-Meal:
/13:25 C4 “11:00” (+2h/) ma#3+4 Nd#? SRP#2 — MlNdSr (1st meal till: ?)
0 D1 “13:00” Pectin and/or psyllium with meal, no other supps.
/17:35 D2/3 “15:00” .5gC#2,Cr#3,.3GA#4/glu#3,gink#2,mal#5+6,NAC#5, “C.Cr.GiGa/Gu.MaNc”
->19:35? D4 “17:00” (“meal/acids+2h”) Nd#?.Qc#1+2.Q10#2.Rs#2,SRP#3. “Nd&Q1QcRsSr2” >19:15
eve:
“18:00” Prepare: 1) Complete & C changed supps. 3) Complete ##. 4) Tally irreg. 5) Remove “v” 6) Cut template 7) Save this 8) Paste 1x & unhide & paste 2nd (+1 to date and ##). BATCHES OK?
(Nov 4th: 18:00 vitamin B12 5mg methylcobalamin s.c.; next: Jan 4th.)

The day's 16 compartments (10', plus 5-10' making capsules)

Try stopping C, NAC & theophylline (tea/cocoa)
Arg: Capsules? Pf: A1+3+4+B1, (0 Nia+) B2:A1+C2 C:C2,D3 Cr: A1+C1+D2, Ga: A3,a4,C1,d2, Glu: A3,a4,d3, Gi: C2,D3, (0Gly: A1+C2+C3), Mal: A2+C4+D3, Nc: A3, B1,C1,C3,D2, Q1QcRs: B3,D4 Sr2x: B1,C4,D4. SINGLE: A2:P5/Ro, B3:Sa C2: Th+Zn.
(A2:0Se)(A2:Ω/Pq:meal), (B2:0mu), (B4: 5NADH if nec.) (D1:0Pe).

Development:
Jab-sfx:
Research-search today:

OK, my jab-sfx apparently may be caused by histamine, so here comes a symptom comparison:

All the flu-like and similar-to-fibro symptoms fit…:

Also the bouts of feeling well.
Skin: itchy, burning, showering & therapy very unpleasant.
Fatigue: exhaustion, exhaustibility, movement, short breathed, stiffer.
Chronic pain: ache from too much movement, sore muscle, e.g. in backside sometimes.
Fluey: Congested nose, sore throat, feverish-feeling, headaches sometimes.
Cold/heat: Usually cold, but then very suddenly terrible heat.
GI: Nausea. Esophagus blocks (similar to eosinophilic esophagitis).
Only thing I can’t find is burnt tongue (unless “burnt mouth”) or seizures (caused by antihistamines or low levels of histamine).
OTOH 4 symptoms I hadn’t seen before are the strange bouts of feeling well, the congested nose when I feel “histaminey”, the sudden bouts of overheating and the increased & changed esophagus blocks while eating.

So: it does seem to be a belated histamine reaction, but not local, like some studies suggest.

Looking at the studies etc. (needs to be re-arranged better)

For histamine, verywellhealth recommends copper - haven’t tried that yet. One of the symptoms they name and I keep having esp. when also feeling overheated and itchy & burning is: a “congested nose”. A histamine challenge may also help diagnose an intolerance. Symptoms may be reduced by 3-4 weeks.
Paleoplan says 14-30 days. Further symptoms I have are nausea and fatigue.
Healinghistamine lists chronic pain, difficulty regulating body temperature, as well as the skin problems like itching mentioned already, also acid & IBS (IBD) even tho I have that under control, B12 which is usually a bit too low unless I supplement, shortness of breath, brain fog, skin on fire (eye problems?)1
Amy Myers MD might be a more reputable exact source, however a functional doc talking about leaky gut.
This study from 2020: Histamine Intolerance: The Current State of the Art says histamine intolerance is now accepted.
Vaccine/FMS-experts
Mast cells in FM

HISTAMINE / Antihistamine Links: Symptoms fit; diet or take DAO? If DAO needs to be increased, why is taking vit. C and NAC and theophylline recommended by Klimas, altho they decrease it?

German wp
low histamine diet
low Histamine diet
low histamine problems: cocoa butter instead of chocolate??
German - diet
German Unverträglichkeit
Amy Myers MD https://www.amymyersmd.com/article/histamine-intolerance/#Common_Symptoms_of_Histamine_Intolerance
State of the Art: Like diclo (so what about aspirin and ibuprofen?), NAC and vitamin C reduce DAO: why shoud I take them together according to Klimas? Histamine Intolerance: The Current State of the Art Also: Longer diet than 4 weeks doesn’t increase it’s success. 5.4.2: TAKING DAO: Porcine DAO activity values ranging from 0.04 to 0.20 mU/m. … Specifically, the germinated sprouts of certain edible legumes have been pointed out as interesting sources of DAO enzyme. … Moreover, certain inflammatory bowel diseases that limit enzyme secretion or some DAO-inhibiting drugs have also been identified as possible causes of DAO deficiency. … Research is currently also being made to identify new sources of DAO enzyme, especially of plant origin, due to its higher catalytic capacity and other potential productive and commercial advantages.
DAO-supplement could help: Histamine Intolerance-The More We Know the Less We Know. A Review - PubMed
DAO:
DAOVET didn’t help: Veterinärmedizinische Universität Wien Forschungsinformationssystem VetDoc
Nichts über DAO-Einnahme, nur Diät, sonst seriös: Wenn Essen krank macht
wpd Diaminoxidase – Wikipedia
Luteolin
On healinghistamine and on a German site it says theophylline blocks DAO. I then don’t understand why I should be supplementing it according to Klimas, as DAO is necessary to get histamine down??
Same goes for vitamin C and NAC according to another study. So I’m stopping them.

Relationship of histamine to cytokines: Study “histamine-mediated cytokines”: Altered esophageal histamine receptor expression in Eosinophilic Esophagitis (EoE): implications on disease pathogenesis - PubMed

EoE, eosinophilic esophagitis would relate my esophagus blocks to histamine and cytokines.

EoE and FM (opera) via GERD/autoimmune: Eosinophilic Esophagitis and Fibromyalgia - Redorbit
Mayo Clinic Eosinophilic esophagitis - Symptoms and causes - Mayo Clinic
EoE Diagnosis and Treatment 2020: Diagnosis and Treatment of Eosinophilic Esophagitis
Role of environment The Role of the Environment in Eosinophilic Esophagitis - PubMed
Biological therapies 2018: Biological Therapies for Eosinophilic Esophagitis: Where Do We Stand? - PubMed
EoE Update 2020 new treatments coming up: Challenges and updates in the management of eosinophilic esophagitis - PubMed
(2020:) New Perspectives in Food Allergy - PubMed
German wikipedia: Eosinophile Ösophagitis – Wikipedia

Cytokines: Studies differentiating pro-inflammatory IL-6 and IL-8 from anti-inflammatory IL-4, IL-5 and IL-13; no storms in vaccines, but storms in CoV, FM

Pfizer/BioNTech changes innate & adaptive immune response 2020 (D, NL) The BNT162b2 mRNA vaccine against SARS-CoV-2 reprograms both adaptive and innate immune responses, see also Research suggests Pfizer-BioNTech COVID-19 vaccine reprograms innate immune responses = Europe PMC
Vaccine Immune response (immediate) AAAS?
No cytokine storm thru vaccines: What do we know about the mRNA vaccine and cytokine storm?
Also: You asked, we answered: Are people who have gotten the COVID-19 vaccines at greater risk for cytokine storms? | Nebraska Medicine Omaha, NE
Cytokine storms thru CoV: The cytokine storm and COVID-19 - PubMed
Cytokine storms CoV 2020: Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies
Cytokine storms wp: Cytokine storm - Wikipedia
Cytokine differentiation (MS) 2016: The use of immune modulating drugs for the treatment of multiple sclerosis
Cytokines differentiation FM comorbid with SS study 2021: Higher Risk for Sjögren’s Syndrome in Patients With Fibromyalgia: A Nationwide Population-Based Cohort Study
Cytokines FM - Goebel’s study is specifically NOT cytokines, it’s trying to circumnavigate them: Study Suggests Something in the Blood is Causing Fibromyalgia - Health Rising
Cytokines in FM 2016 - differentiation Neurobiology of fibromyalgia and chronic widespread pain
Cytokines in FM 2014 - Unique Cytokine Signature in the Plasma of Patients with Fibromyalgia
Goebel is not cytokines: Fibromyalgia likely the result of autoimmune problems -- ScienceDaily
Cytokines FM study: Serum proteome profiles revealed dysregulated proteins and mechanisms associated with fibromyalgia syndrome in women
Cytokines FM comorbid with AS study: Patients With Ankylosing Spondylitis Are Associated With High Risk of Fibromyalgia: A Nationwide Population-Based Cohort Study
Cytokines: Interleukins: Interleukin - Wikipedia
(Cytokines not improved by exercise study Plasma Cytokine Levels in Fibromyalgia and Their Response to 15 Weeks of Progressive Resistance Exercise or Relaxation Therapy)

CoV Vaccines: don't weaken the immune system, can have belated !local allergic reactions, first jab start getting effective after 3 weeks

Vaccines don’t weaken the immune system: No scientific evidence for claim by pathologist Ryan Cole that COVID-19 vaccines weaken the immune system - Health Feedback
Allergic reactions AAAS As with other vaccines, these effects can, on rare occasion, be the result of delayed-onset, local allergic reactions.
Effectiveness 36.8% 3 weeks after 1st dose Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar Estimated BNT162b2 effectiveness against any SARS-CoV-2 infection was negligible in the first 2 weeks after the first dose. It increased to 36.8% (95% confidence interval [CI], 33.2 to 40.2) in the third week after the first dose

FM update: STILL TENDER POINTS 2021! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8068842/
This daring clinic “can heal everything, FM, EoE, whatever…” :wink: Eosinophilic Esophagitis Sufferer Greatly Improved - The Goldberg Tener Clinic

Lessons in self-care #178: Let my mind get carried away last night, which was to a good end, but need to catch up with more sleep tonight.
Lessons in self-care #179: Did nothing much except the 2 docs today.
Reasons to be cheerful #190: I feel very self-advocating & self-efficient now I understand cytokines better and am pretty sure of the histamine intolerance.