Rhodiola rosea seems to help amino acids - & also be anti-inflammatory
Looking again at this healthfully page, I’m discovering more connections.
What I’ve already taking note of is them pointing to 500 mg L-tyrosine and 25 mg of vitamin B6 in the mornings to increase dopamine, and L-tryptophan in the evenings to increase serotonin (tho the studies are old). I admit I haven’t really digested it tho. Personally, I have to watch out more for my sfx, esp. seizures. I get these if I increase dopamine, or serotonin too much, and as that was the case I shdnt be increasing either more than I have been, or watch for the balance.
But what it also says (lower on the same page at the mo), with a different URL, is to take 50mg of 5-HTP and also 200-600mg Rhodiola rosalea (roseroot, rosewort, Rosenwurz) for serotonin. But the latter also - referring to drugs.com - to increase the permeability of the Blood-Brain-Barrier, which allows precursors to serotonin and other neurotransmitters and https://www.drugs.com/npp/rhodiola-rosea.html, which itself refers to several studies:
“Depression
CNS activity of R. rosea has been reported.12 Earlier studies found that low to medium doses of the plant had stimulatory effects, while larger doses had sedative effects.2 In lower doses, R. rosea stimulated norepinephrine, dopamine, serotonin, and nicotinic cholinergic systems in the CNS. R. rosea also increased the permeability of the blood-brain barrier to precursors of dopamine and serotonin41, 42, 43 and improved cerebral circulation.44 In an in vitro study, R. rosea root extract inhibited monoamine oxidases A and B.45”
These are the articles referred to, 1986-2009
12: 12. Panossian A, Wagner H. Stimulating effect of adaptogens: an overview with particular reference to their efficacy following single dose administration. Phytother Res . 2005;19(10):819-838.16261511
2. Brown RP, Gerbarg PL, Ramazanov Z. Rhodiola rosea : a phytomedicinal overview. HerbalGram . 2002;56:40-52.
41. Kurkin VA, Zapesochnaya GG. Chemical composition and pharmacological properties of Rhodiola rosea . Chem Pharm J . 1986;20(10):1231-1244.42. Petkov VD, Yonkov D, Mosharoff A, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg . 1986;12(1):3-16.375162343. Saratikov A, Marina TF, Fisanova LL. Effect of golden root extract on processes of serotonin synthesis in CNS. J Biol Sci . 1978;6:142.
44. Pogorelyĭ VE, Makarova LM. Rhodiola rosea extract for prophylaxis of ischemic cerebral circulation disorder [in Russian]. Eksp Klin Farmakol . 2002;65(4):19-22.1244906945. van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol . 2009;122(2):397-401.19168123
Now my doc had prescribed “rosalea” to get my blood pressure down, which it now is, altho nothing on this page mentions blood pressure.
So I’m having a look for more modern studies and am pleased to find even more goodies:
Seems to be anti-inflammatory Anti-inflammatory effects of Rhodiola rosea L.: A review - ScienceDirect, mainly due to the salidroside in it.
Studies from 2021
A combination of green tea, rhodiola, magnesium and B vitamins modulates brain activity and protects against the effects of induced social stress in healthy volunteers - PubMed 2021: help with stress in combination.
The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular and Metabolic Diseases: An Updated Review - PubMed 2021: Might be good.
A supercritical fluid workflow for the quality assessment of herbal drugs and commercial preparations from Rhodiola rosea - PubMed 2021: A quick way to control the quality of the compound.
Quality Evaluation of Randomized Controlled Trials of Rhodiola Species: A Systematic Review - PubMed 2021: Still no good trials.
(cf. Rhodiola rosea for physical and mental fatigue: a systematic review - PubMed (2012: all trials have a high risk of bias))
Dietary Supplement Ingredients for Optimizing Cognitive Performance Among Healthy Adults: A Systematic Review - PubMed 2021: Better trials needed.
Running out of time to smell the roseroots: Reviewing threats and trade in wild Rhodiola rosea L - PubMed 2021: Due to the demand & things like illegal harvesting, the real wild plant needs to be protected.