I have been taking Savella for 4 or 6 yrs now. The 'script is 2 - 50mg/day, I tried to do the one in the AM & one in the PM, but the AM one would Kick my Fanny! I felt like a sleepwalker, it was Horrible. I now take 2@ 7P & I have noticed that if I don’t take the Med, I Feel it. Both my PCP & Pharmacist worked Hard to get me this Med. Does your MD have “The Closet”? It is where the samples are for the less unfortunate patients. Have you gone to your MD’s office during a Flare? It puts them into a certain perspective that they think “OOOOOOooooooh, sit (with an h in it)”. I was asked about the muscle relaxant I told him it didn’t work & gave it back to the pharmacist. So I was 'scripted a stronger relaxer & a nausea pill for the pain pill. Yes we are like snowflakes, not a one of us has the same chemistry. I am Glad you have an MD like I have. We both have learned together about this challenging syndrome, disease, thingy. Peace, Love & Light. Maggi.